_____________________________________________________________________

TGFB1 (transforming growth factor beta) Rules

___

Author:
Beatriz Santos November, 3 2017

Contents

1 Initial State: TNFDish
2 Comparison of breast cancer subtypes
 2.1 HER2 vs LUMA
 2.2 HER2 vs LUMB
 2.3 HER2 vs BASAL
 2.4 LUMA vs BASAL
 2.5 LUMB vs BASAL
 2.6 LUMA vs LUMB
3 Classification of rules by breast cancer subtypes
 3.1 In all subtypes
 3.2 In Her2, lumA, lumB
 3.3 In Her2, LumA, Basal
 3.4 In Her2, LumB, Basal
 3.5 In LumA, LumB, Basal
 3.6 In Her2, lumA
 3.7 In Her2, LumB
 3.8 In Her2, Basal
 3.9 In LumA, lumB
 3.10 In LumB, Basal
 3.11 In LumA, Basal
 3.12 Only in LumA
 3.13 Only in LumB
 3.14 Only in Her2
 3.15 Only in Basal
 3.16 Not in any subtype

1 Initial State: TNFDish

http://stella.csl.sri.com/~pl/Evidence/STM7/SDishes/Tgfb1Dish.maude




Figure 1: TGFB1 Dish (initial state) simplified. Rules that do not appear in any subtype were erased. The remaining ones are classified into subtypes.

eq Tgfb1Dish = PD( 
{XOut    |  Tgfb1 } 
{Tgfb1RC | TgfbR1 TgfbR2  } 
{CLo   | empty } 
{CLm   | empty } 
{CLi   | [Cdc42 - GDP] [Hras - GDP] [Rac1 - GDP] } 
{CLc   | Abl1 Akt1 Atf2 Erks Fak1 Jnks Mekk1 Mlk3 P38s Pak2 Pml Smad2 Smad3 Smad4 Smurf1 Smurf2 Tab1 Tab2 Tab3 Tak1 Traf6 Zfyve16 } 
{NUc   | 
Ctdsp1 Ets1 Smad7 Cdc6-gene Cdkn1a-gene Cdkn2b-gene Col1a1-gene Col3a1-gene Ctgf-gene Fn1-gene Mmp2-gene Pai1-gene Smad6-gene Smad7-gene Tgfb1-gene Timp1-gene Cst6-gene Dst-gene Mmp9-gene Mylk-gene Pthlh-gene Gfi1-gene Csrp2-gene RoRc-gene }) .

2 Comparison of breast cancer subtypes

2.1 HER2 vs LUMA




Figure 2: Graph comparing Her2 vs LumA. Pink occurrences and rules are common to both Her2 and LumA. Blue occurrences and rules are only in LumA. Purple occurrences and rules are only in Her2.

2.2 HER2 vs LUMB




Figure 3: Graph comparing Her2 vs LumB. Pink occurrences and rules are common to both Her2 and LumB. Blue occurrences and rules are only in LumB. Purple occurrences and rules are only in Her2.

2.3 HER2 vs BASAL




Figure 4: Graph comparing Her2 vs Basal. Pink occurrences and rules are common to both Her2 and Basal. Blue occurrences and rules are only in Basal. Purple occurrences and rules are only in Her2.

2.4 LUMA vs BASAL




Figure 5: Graph comparing lumA vs Basal. Pink occurrences and rules are common to both lumA and Basal. Blue occurrences and rules are only in Basal. Purple occurrences and rules are only in lumA.

2.5 LUMB vs BASAL




Figure 6: Graph comparing LumB vs Basal. Pink occurrences and rules are common to both LumB and Basal. Blue occurrences and rules are only in Basal. Purple occurrences and rules are only in lumB.

2.6 LUMA vs LUMB




Figure 7: Graph comparing LumA vs lumB. Pink occurrences and rules are common to both LumA and lumB. Blue occurrences and rules are only in lumB. Purple occurrences and rules are only in lumA.

3 Classification of rules by breast cancer subtypes

3.1 In all subtypes

Rewrite Rule 931

rl[931.TgfbR1.TgfbR2.by.Tgfb1]: 
  {XOut    | xout Tgfb1                                        } 
  {Tgfb1RC | tgfb1rc  TgfbR1 TgfbR2                            } 
  => 
  {XOut    | xout                                              } 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } . 
  ---------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/TgfbR1.TgfbR2.by.Tgfb1.931.txt

3.2 In Her2, lumA, lumB

none

3.3 In Her2, LumA, Basal

none

3.4 In Her2, LumB, Basal

Rewrite Rule 1724

rl[1724.Cdc6-gene.irt.Tgfb1]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {NUc     | nuc       Cdc6-gene                             } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {NUc     | nuc      [Cdc6-gene - on]                       } . 
  ---------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Cdc6-gene.irt.Tgfb1.1724.txt

3.5 In LumA, LumB, Basal

none

3.6 In Her2, lumA

none

3.7 In Her2, LumB

none

3.8 In Her2, Basal

none

3.9 In LumA, lumB

Rewrite Rule 415c

rl[415c.Erks.act]: 
  {AnyLoc | anyloc [Erks - erksmods phos(TEY)]     } 
  => 
  {AnyLoc | anyloc [Erks - erksmods act phos(TEY)] } . 
  ------------------------------------------------------- 
  *** ~/Repositories/IOP++/PLA4/Package/Models/STM7/evidence/Common-Rule-Evidence/Erks.act.415c.txt

Rewrite Rules 921, 921-1

rl[921.Erks.irt.Tgfb1]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {CLi     | cli     [Hras - GTP] 
                     ([cr:Cdc42Rac1S - GTP] : [Pak2 - act])    } 
  {CLc     | clc      Erks                                     } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {CLi     | cli     [Hras - GTP] 
                     ([cr:Cdc42Rac1S - GTP] : [Pak2 - act])    } 
  {CLc     | clc      [Erks - phos(TEY)]                       } . 
  ---------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Erks.irt.Tgfb1.921.txt

Rewrite Rule 1708

rl[1708.Cdc42.irt.Tgfb1]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {CLi     | cli    [Cdc42 - GDP]                              } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {CLi     | cli    [Cdc42 - GTP]                              } . 
  ---------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Cdc42.irt.Tgfb1.1708.txt

Rewrite Rules 1709-1, 1709-2, 1709-4, 1709-5

rl[1709.Pak2.irt.Tgfb1]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {CLi     | cli     ([cr:Cdc42Rac1S - GTP] : Pak2)            } 
  {CLc     | clc      [Fak1 - fak1mods]                        } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {CLi     | cli     ([cr:Cdc42Rac1S - GTP] : [Pak2 - act])    } 
  {CLc     | clc      [Fak1 - fak1mods]                        } . 
  ---------------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Pak2.irt.Tgfb1.1709.txt

Rewrite Rules 1710, 1710-1

rl[1710.Pak2.to.Cdc42Rac1s]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {CLi     | cli      [cr:Cdc42Rac1S - GTP]                    } 
  {CLc     | clc      Pak2                                     } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {CLi     | cli     ([cr:Cdc42Rac1S - GTP] : Pak2)            } 
  {CLc     | clc                                               } . 
  ---------------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Pak2.to.Cdc42Rac1s.1710.txt

Rewrite Rule 1711

rl[1711.Rac1.irt.Tgfb1]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {CLi     | cli    [Rac1 - GDP]                               } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {CLi     | cli    [Rac1 - GTP]                               } . 
  ---------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Rac1.irt.Tgfb1.1711.txt

Rewrite Rule 1720

rl[1720.Fak1.irt.Tgfb1]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1)     } 
  {CLc     | clc      Fak1                                         } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1)     } 
  {CLc     | clc      [Fak1 - phos(Y 397) phos(Y 577) phos(Y 925)] } . 
  -------------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Fak1.irt.Tgfb1.1720.txt

Rewrite Rule 1722

rl[1722.Hras.irt.Tgfb1]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {CLi     | cli     [Hras - GDP]                              } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {CLi     | cli     [Hras - GTP]                              } . 
  ---------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Hras.irt.Tgfb1.1722.txt

3.10 In LumB, Basal

Rewrite Rules 1735, 1735-1

rl[1735.Tak1.to.Tgfb1RC]: 
  {Tgfb1RC | tgfb1rc  TgfbR1 TgfbR2                               } 
  {CLc     | clc      (Tak1 : Tab1 : tab23s:Tab23S)               } 
  => 
  {Tgfb1RC | tgfb1rc  TgfbR1 TgfbR2 (Tak1 : Tab1 : tab23s:Tab23S) } 
  {CLc     | clc                                                  } . 
  ----------------------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Tak1.to.Tgfb1RC.1735.txt

Rewrite Rule 1736

rl[1736.Traf6.to.Tgfb1RC]: 
  {Tgfb1RC | tgfb1rc  TgfbR1 TgfbR2                               } 
  {CLc     | clc      Traf6                                       } 
  => 
  {Tgfb1RC | tgfb1rc  TgfbR1 TgfbR2 Traf6                         } 
  {CLc     | clc                                                  } . 
  ----------------------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Traf6.to.Tgfb1RC.1736.txt

Rewrite Rule 924

rl[924.Smad3.to.Tgfb1RC]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1)       } 
  {CLc     | clc     Smad3                                           } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) Smad3 } 
  {CLc     | clc                                                     } . 
  ---------------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Smad3.to.Tgfb1RC.924.txt

Rewrite Rule 929, 929-1

rl[929.Jnks.irt.Tgfb1]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) 
                     ([Tak1 - act tak1mods] : Tab1 : tab23s:Tab23S)  } 
  {CLc     | clc     Jnks                                            } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) 
                     ([Tak1 - act tak1mods] : Tab1 : tab23s:Tab23S)  } 
  {CLc     | clc     [Jnks - act]                                    } . 
  ----------------------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Jnks.irt.Tgfb1.929.txt

Rewrite Rule 1589, 1589-1

rl[1589.Tak1.ubiq.irt.Tgfb1]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) 
                      [Traf6 - ubiq] 
                     (Tak1 : Tab1 : tab23s:Tab23S)              } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) 
                      [Traf6 - ubiq] 
                     ([Tak1 - K63ubiq] : Tab1 : tab23s:Tab23S)  } . 
  ----------------------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Tak1.ubiq.irt.Tgfb1.1589.txt

Rewrite Rule 1590

rl[1590.Traf6.ubiq.irt.Tgfb1]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) Traf6          } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) [Traf6 - ubiq] }. 
  ------------------------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Traf6.ubiq.irt.Tgfb1.1590.txt

Rewrite Rule 555c, 555c-1

rl[555c.Tab1.Tab23.Tak1.complex]: 
  {CLc | clc  Tab1   tab23:Tab23S   Tak1  } 
  => 
  {CLc | clc (Tab1 : tab23:Tab23S : Tak1) } . 
  ------------------------------------------------------------------- 
  *** ~/Repositories/IOP++/PLA4/Package/Models/STM7/evidence/Common-Rule-Evidence/Tab1.Tab23.Tak1.complex.555c.txt

Rewrite Rule 560

rl[560.Smad3.phos.irt.Tgfb1]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) 
                       Smad3                                                } 
  {CLc     | clc     [Jnks - act]                                           } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) 
                     [Smad3 - phos(S 423)phos(S 425)phos(S 416)phos(S 418)] } 
  {CLc     | clc     [Jnks - act]                                           } . 
  ------------------------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Smad3.phos.irt.Tgfb1.560.txt

Rewrite Rule 641, 641-1

rl[641.Tak1.phos.irt.Tgfb1]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) 
                      [Traf6 - ubiq] 
                     ([Tak1 - K63ubiq] : Tab1 : tab23s:Tab23S)          } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) 
                      [Traf6 - ubiq] 
                     ([Tak1 - K63ubiq act phos] : Tab1 : tab23s:Tab23S) } . 
  ----------------------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Tak1.phos.irt.Tgfb1.641.txt

Rewrite Rule 731

rl[731.Smad3.to.nuc.irt.Tgfb1]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) 
                     [Smad3 - smad3mods phos(S 416)phos(S 418)]    } 
  {CLc     | clc     Pml                                           } 
  {NUc     | nuc                                                   } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1)     } 
  {CLc     | clc     Pml                                           } 
  {NUc     | nuc     [Smad3 - smad3mods phos(S 416)phos(S 418)]    } . 
  --------------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Smad3.to.nuc.irt.Tgfb1.731.txt

Rewrite Rule 845

rl[845.Smad3.act.irt.Tgfb1]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {NUc     | nuc     [Smad3 - smad3mods]                       } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {NUc     | nuc     [Smad3 - smad3mods act]                   } . 
  ---------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Smad3.act.irt.Tgfb1.845.txt

3.11 In LumA, Basal

none

3.12 Only in LumA

Rewrite Rule 182

rl[182.Smad2.Smad4.irt.Tgfb1]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {CLc     | clc     Zfyve16                                   } 
  {NUc     | nuc     [Smad2 - smad2mods] Smad4                 } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {CLc     | clc     Zfyve16                                   } 
  {NUc     | nuc     ([Smad2 - smad2mods] : Smad4)             } . 
  ---------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Smad2.Smad4.irt.Tgfb1.182.txt

Rewrite Rule 473c

rl[473c.Mekk1.by.Rac1]: 
  {CLi | cli [Rac1 - GTP] } 
  {CLc | clc Mekk1 } 
  => 
  {CLi | cli [Rac1 - GTP] } 
  {CLc | clc [Mekk1 - act] } . 
  ----------------------------------------------------------- 
  *** ~/Repositories/IOP++/PLA4/Package/Models/STM7/evidence/Common-Rule-Evidence/Mekk1.by.Rac1.473c.txt

Rewrite Rule 1827

rl[1827.RoRc-gene.irt.Tgfb1]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1)   } 
  {NUc     | nuc      RoRc-gene                                  } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1)   } 
  {NUc     | nuc      [RoRc-gene - on]                           } . 
  ------------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/RoRc-gene.irt.Tgfb1.1827.txt

3.13 Only in LumB

Rewrite Rule 737-1

rl[737.Smad3.Smad4.irt.Tgfb1]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {NUc     | nuc     [Smad3 - smad3mods] Smad4                 } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {NUc     | nuc     ([Smad3 - smad3mods] : Smad4)             } . 
  ---------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Smad3.Smad4.irt.Tgfb1.737.txt

Rewrite Rule 768

rl[768.Smad4.to.nuc.irt.Tgfb1]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {CLc     | clc     Smad4                                     } 
  {NUc     | nuc                                               } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {CLc     | clc                                               } 
  {NUc     | nuc     Smad4                                     } . 
  ---------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Smad4.to.nuc.irt.Tgfb1.768.txt

3.14 Only in Her2

Rewrite Rule 915

rl[915.Akt1.irt.Tgfb1]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {CLc     | clc      Akt1                                     } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {CLc     | clc      [Akt1 - phos(S 473)phos(T 308)]          } . 
  ---------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Akt1.irt.Tgfb1.915.txt

Rewrite Rule 619c

rl[619c.Akt1.act]: 
  {CLc | clc [Akt1 - phos(S 473)phos(T 308)] } 
  => 
  {CLc | clc [Akt1 - act]                    } . 
  ----------------------------------------------------------- 
  *** ~/Repositories/IOP++/PLA4/Package/Models/STM7/evidence/Common-Rule-Evidence/Akt1.act.619c.txt

3.15 Only in Basal

Rewrite Rules 648, 648-1

rl[648.Mmp9-gene.irt.Tgfb1]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1)  } 
  {NUc     | nuc      [Smad2 - smad2mods act] 
                      [Smad3 - smad3mods act]  Mmp9-gene        } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1)  } 
  {NUc     | nuc      [Smad2 - smad2mods act] 
                      [Smad3 - smad3mods act] [Mmp9-gene - on]  } . 
  -------------------------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Mmp9-gene.irt.Tgfb1.648.txt

Rewrite Rule 673

rl[673.Smad2.to.nuc.irt.Tgfb1]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) 
                     [Smad2 - smad2mods phos(S 465)phos(S 467)]  } 
  {NUc     | nuc                                                 } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1)   } 
  {NUc     | nuc     [Smad2 - smad2mods phos(S 465)phos(S 467)]  } . 
  ---------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Smad2.to.nuc.irt.Tgfb1.673.txt

Rewrite Rule 705, 705-1

 
rl[705.Smad2.acetyl.irt.Tgfb1]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {NUc     | nuc     [Smad2 - smad2mods]                       } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {NUc     | nuc     [Smad2 - smad2mods acetyl(K 19)]          } . 
  ---------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Smad2.acetyl.irt.Tgfb1.705.txt

Rewrite Rule 869

rl[869.Smad7.from.nuc.irt.Tgfb1]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1)       } 
  {NUc     | nuc     Smad7                                           } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) Smad7 } 
  {NUc     | nuc                                                     } . 
  ---------------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Smad7.from.nuc.irt.Tgfb1.869.txt

Rewrite Rule 1734

rl[1734.Csrp2-gene.irt.Tgfb1]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1)     } 
  {CLc     | clc      [Atf2 - phos]                                } 
  {NUc     | nuc      [Smad3 - smad3mods act] Csrp2-gene           } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1)     } 
  {CLc     | clc      [Atf2 - phos]                                } 
  {NUc     | nuc      [Smad3 - smad3mods act] [Csrp2-gene - on]    } . 
  -------------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Csrp2-gene.irt.Tgfb1.1734.txt

Rewrite Rule 568

rl[568.Smad2.act.irt.Tgfb1]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {NUc     | nuc     [Smad2 - smad2mods acetyl(K 19)]                    } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {NUc     | nuc     [Smad2 - smad2mods act]                             } . 
  ---------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Smad2.act.irt.Tgfb1.568.txt

Rewrite Rule 569

rl[569.Smad2.to.Tgfb1RC]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1)       } 
  {CLc     | clc     Smad2                                           } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) Smad2 } 
  {CLc     | clc                                                     } . 
  ---------------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Smad2.to.Tgfb1RC.569.txt

Rewrite Rule 1723

rl[1723.Mlk3.irt.Tgfb1]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {CLc     | clc     Mlk3                                      } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {CLc     | clc     [Mlk3 - act]                              } . 
  ---------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Mlk3.irt.Tgfb1.1723.txt

Rewrite Rule 541

rl[541.Atf2.irt.Tgfb1]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {CLc     | clc     [P38s - act] Atf2                         } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {CLc     | clc     [P38s - act] [Atf2 - phos]                } . 
  ---------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Atf2.irt.Tgfb1.541.txt

Rewrite Rule 543, 543-1

rl[543.P38s.irt.Tgfb1]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) Smad7 
                     ([Tak1 - act tak1mods] : Tab1 : tab23s:Tab23S) 
                      [Traf6 - ubiq]                                       } 
  {CLc     | clc     [Mlk3 - act] P38s                                     } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) Smad7 
                     ([Tak1 - act tak1mods] : Tab1 : tab23s:Tab23S) 
                      [Traf6 - ubiq]                                       } 
  {CLc     | clc     [Mlk3 - act] [P38s - act]                             } . 
  ---------------------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/P38s.irt.Tgfb1.543.txt

Rewrite Rule 969

rl[969.Smad2.phos.irt.Tgfb1]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) 
                      [Smad2 - smad2mods]                         } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) 
                      [Smad2 - smad2mods phos(S 465)phos(S 467) ] } . 
  ----------------------------------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Smad2.phos.irt.Tgfb1.969.txt

3.16 Not in any subtype

Rewrite Rule 316

rl[316.Smurf1.to.Tgfb1RC]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) Smad7  } 
  {CLc     | clc     Smurf1                                           } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) Smad7 
                     Smurf1                                           } 
  {CLc     | clc                                                      } . 
  ----------------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Smurf1.to.Tgfb1RC.316.txt

Rewrite Rule 039c

rl[039c.Mekk1.by.Hras]: 
  {CLi | cli [Hras - GTP]       } 
  {CLc | clc  Mekk1             } 
  => 
  {CLi | cli [Hras - GTP] Mekk1 } 
  {CLc | clc                    } . 
  ----------------------------------------------------------- 
  *** ~/Repositories/IOP++/PLA4/Package/Models/STM7/evidence/Common-Rule-Evidence/Mekk1.by.Hras.039c.txt

Rewrite Rule 063c

rl[063c.Atf2.by.P38s]: 
  {CLc | clc [P38s - act]  Atf2                         } 
  => 
  {CLc | clc [P38s - act] [Atf2 - phos(T 69)phos(T 71)] } . 
  ----------------------------------------------------------- 
  *** ~/Repositories/IOP++/PLA4/Package/Models/STM7/evidence/Common-Rule-Evidence/Atf2.by.P38s.063c.txt 
  *** ~/Repositories/IOP++/PLA4/Package/Models/STM7/evidence/Common-Rule-Evidence/Atf2.by.P38a.txt 
  *** ~/Repositories/IOP++/PLA4/Package/Models/STM7/evidence/Common-Rule-Evidence/Atf2.by.P38b.txt 
  *** ~/Repositories/IOP++/PLA4/Package/Models/STM7/evidence/Common-Rule-Evidence/Atf2.by.P38g.txt

Rewrite Rules 182-1, 182-2, 182-3

rl[182.Smad2.Smad4.irt.Tgfb1]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {CLc     | clc     Zfyve16                                   } 
  {NUc     | nuc     [Smad2 - smad2mods] Smad4                 } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {CLc     | clc     Zfyve16                                   } 
  {NUc     | nuc     ([Smad2 - smad2mods] : Smad4)             } . 
  ---------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Smad2.Smad4.irt.Tgfb1.182.txt

Rewrite Rule 213c

rl[213c.Mlk3.by.Akt1]: 
  {CLc | clc [Akt1 - act]  Mlk3         } 
  => 
  {CLc | clc [Akt1 - act] [Mlk3 - phos] } . 
  ----------------------------------------------------------- 
  *** ~/Repositories/IOP++/PLA4/Package/Models/STM7/evidence/Common-Rule-Evidence/Mlk3.by.Akt1.213c.txt

Rewrite Rule 349c

rl[349c.Mekk1.by.Cdc42]: 
  {CLi | cli [Cdc42 - GTP]       } 
  {CLc | clc Mekk1               } 
  => 
  {CLi | cli [Cdc42 - GTP] Mekk1 } 
  {CLc | clc                     } . 
  ----------------------------------------------------------- 
  *** ~/Repositories/IOP++/PLA4/Package/Models/STM7/evidence/Common-Rule-Evidence/Mekk1.by.Cdc42.349c.txt

Rewrite Rule 492

rl[492.Smurf2.to.Tgfb1RC]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) Smad7 } 
  {CLc     | clc     Smurf2                                          } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) Smad7 
                     Smurf2                                          } 
  {CLc     | clc                                                     } . 
  ---------------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Smurf2.to.Tgfb1RC.492.txt

Rewrite Rules 549, 549-1

rl[549.Pai1-gene.irt.Tgfb1]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) 
                     ([Tak1 - act tak1mods] : Tab1 : tab23s:Tab23S)      } 
  {CLc     | clc     Mekk1 Pml Zfyve16                                   } 
  {NUc     | nuc     Ets1 [Smad3 - smad3mods act] Pai1-gene              } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) 
                     ([Tak1 - act tak1mods] : Tab1 : tab23s:Tab23S)      } 
  {CLc     | clc     Mekk1 Pml Zfyve16                                   } 
  {NUc     | nuc     Ets1 [Smad3 - smad3mods act] [Pai1-gene - on]       } . 
  -------------------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Pai1-gene.irt.Tgfb1.549.txt

Rewrite Rule 567

rl[567.Smad7-gene.irt.Tgfb1]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {NUc     | nuc     ctdsps:CtdspS Smad7-gene                  } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {NUc     | nuc     ctdsps:CtdspS [Smad7-gene - on]           } . 
  ---------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Smad7-gene.irt.Tgfb1.567.txt

Rewrite Rule 737

rl[737.Smad3.Smad4.irt.Tgfb1]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {NUc     | nuc     [Smad3 - smad3mods] Smad4                 } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {NUc     | nuc     ([Smad3 - smad3mods] : Smad4)             } . 
  ---------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Smad3.Smad4.irt.Tgfb1.737.txt

Rewrite Rule 738c

rl[738c.Smad2.by.Jnks]: 
  {CLc | clc [Jnks - act] Smad2                              } 
  => 
  {CLc | clc [Jnks - act] [Smad2 - phos(S 250) phos(S 255) ] } . 
  ---------------------------------------------------------------------- 
  *** ~/Repositories/IOP++/PLA4/Package/Models/STM7/evidence/Common-Rule-Evidence/Smad2.by.Jnks.738c.txt

Rewrite Rule 764c

rl[764c.Smad3.by.Jnks]: 
  {CLc | clc [Jnks - act] Smad3                              } 
  => 
  {CLc | clc [Jnks - act] [Smad3 - phos(S 208) phos(S 213) ] } . 
  ---------------------------------------------------------------------- 
  *** ~/Repositories/IOP++/PLA4/Package/Models/STM7/evidence/Common-Rule-Evidence/Smad3.by.Jnks.764c.txt

Rewrite Rule 875

rl[875.TgfbR1.ubiq.by.Smurf1]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) 
                     Smad7 Smurf1                               } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - ubiq] : [TgfbR2 - act] : Tgfb1) 
                     Smad7 Smurf1                               } . 
  ---------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/TgfbR1.ubiq.by.Smurf1.875.txt

Rewrite Rules 902, 902-1, 902-2, 902-3

rl[902.Cdkn1a-gene.irt.Tgfb1]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1)    } 
  {NUc     | nuc      Ets1 [Smad2 - smad2mods] Cdkn1a-gene        } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1)    } 
  {NUc     | nuc      Ets1 [Smad2 - smad2mods] [Cdkn1a-gene - on] } . 
  ------------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Cdkn1a-gene.irt.Tgfb1.902.txt

Rewrite Rule 904

rl[904.Cdkn2b-gene.irt.Tgfb1]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {NUc     | nuc       Cdkn2b-gene                             } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {NUc     | nuc      [Cdkn2b-gene - on]                       } . 
  ---------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Cdkn2b-gene.irt.Tgfb1.904.txt

Rewrite Rule 910

rl[910.Smad6-gene.irt.Tgfb1]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {NUc     | nuc       Smad6-gene                              } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {NUc     | nuc      [Smad6-gene - on]                        } . 
  ---------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Smad6-gene.irt.Tgfb1.910.txt

Rewrite Rules 1067c-3

rl[1067c.Smad2.by.Erks]: 
  {CLc | clc [Erks - erksmods act] Smad2         } 
  => 
  {CLc | clc [Erks - erksmods act] [Smad2 - phos] } . 
  ---------------------------------------------------------------------- 
  *** ~/Repositories/IOP++/PLA4/Package/Models/STM7/evidence/Common-Rule-Evidence/Smad2.by.Erks.1067c.txt

Rewrite Rules 1712-1, 1712-2

rl[1712.Fn1-gene.irt.Tgfb1]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {CLc     | clc      [Fak1 - fak1mods]                        } 
  {NUc     | nuc     Fn1-gene                                  } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {CLc     | clc      [Fak1 - fak1mods]                        } 
  {NUc     | nuc     [Fn1-gene - on]                           } . 
  ---------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Fn1-gene.irt.Tgfb1.1712.txt

Rewrite Rule 1713

  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {CLc     | clc      [Fak1 - fak1mods phos(Y 397)]            } 
  {NUc     | nuc       Col1a1-gene                             } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {CLc     | clc      [Fak1 - fak1mods phos(Y 397)]            } 
  {NUc     | nuc      [Col1a1-gene - on]                       } . 
  ---------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Col1a1-gene.irt.Tgfb1.1713.txt

Rewrite Rule 1714

rl[1714.Col3a1-gene.irt.Tgfb1]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {NUc     | nuc       Col3a1-gene                             } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {NUc     | nuc      [Col3a1-gene - on]                       } . 
  ---------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Col3a1-gene.irt.Tgfb1.1714.txt

Rewrite Rule 1715

rl[1715.Ctgf-gene.irt.Tgfb1]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {NUc     | nuc       Ctgf-gene                               } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {NUc     | nuc      [Ctgf-gene - on]                         } . 
  ---------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Ctgf-gene.irt.Tgfb1.1715.txt

Rewrite Rule 1716

rl[1716.Mmp2-gene.irt.Tgfb1]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {NUc     | nuc       Mmp2-gene                               } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {NUc     | nuc      [Mmp2-gene - on]                         } . 
  ---------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Mmp2-gene.irt.Tgfb1.1716.txt

Rewrite Rule 1717

  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {NUc     | nuc       Tgfb1-gene                              } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {NUc     | nuc      [Tgfb1-gene - on]                        } . 
  ---------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Tgfb1-gene.irt.Tgfb1.1717.txt

Rewrite Rule 1718

rl[1718.Timp1-gene.irt.Tgfb1]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {NUc     | nuc       Timp1-gene                              } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {NUc     | nuc      [Timp1-gene - on]                        } . 
  ---------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Timp1-gene.irt.Tgfb1.1718.txt

Rewrite Rules 1719-1, 1719-2

rl[1719.Abl1.irt.Tgfb1]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {CLc     | clc      [Fak1 - fak1mods] Abl1                   } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {CLc     | clc      [Fak1 - fak1mods] [Abl1 - act]           } . 
  ---------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Abl1.irt.Tgfb1.1719.txt

Rewrite Rule 1725

rl[1725.Cst6-gene.irt.Tgfb1]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1)     } 
  {NUc     | nuc      [Smad3 - smad3mods act] Cst6-gene            } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1)     } 
  {NUc     | nuc      [Smad3 - smad3mods act] [Cst6-gene - on]     } . 
  -------------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Cst6-gene.irt.Tgfb1.1725.txt

Rewrite Rules 1726, 1726-1, 1726-2, 1726-3

rl[1726.Dst-gene.irt.Tgfb1]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {NUc     | nuc      [Smad2 - smad2mods] Dst-gene             } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1) } 
  {NUc     | nuc      [Smad2 - smad2mods] [Dst-gene - on]      } . 
  ---------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Dst-gene.irt.Tgfb1.1726.txt

Rewrite Rules 1727, 1727-1, 1727-2, 1727-3

rl[1727.Mylk-gene.irt.Tgfb1]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1)  } 
  {NUc     | nuc      [Smad2 - smad2mods] Mylk-gene             } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1)  } 
  {NUc     | nuc      [Smad2 - smad2mods] [Mylk-gene - on]      } . 
  ----------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Mylk-gene.irt.Tgfb1.1727.txt

Rewrite Rule 1728

rl[1728.Pthlh-gene.irt.Tgfb1]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1)   } 
  {NUc     | nuc      Pthlh-gene                                 } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1)   } 
  {NUc     | nuc      [Pthlh-gene - on]                          } . 
  ------------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Pthlh-gene.irt.Tgfb1.1728.txt

Rewrite Rule 1733

rl[1733.Gfi1-gene.irt.Tgfb1]: 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1)  } 
  {NUc     | nuc      Gfi1-gene                                 } 
  => 
  {Tgfb1RC | tgfb1rc ([TgfbR1 - act] : [TgfbR2 - act] : Tgfb1)  } 
  {NUc     | nuc      [Gfi1-gene - off]                         } . 
  ----------------------------------------------------------------- 
  *** ~/evidence/Tgfb1-Evidence/Gfi1-gene.irt.Tgfb1.1733.txt